CTO Stream is Clinical Trials Ontario’s web-based platform that supports ethics approval and oversight by a single REB for multisite research studies in Ontario. CTO is pleased to announce that the program now welcomes applications for ethics review from Observational Research Studies (in addition to clinical trials). A single CTO Qualified Research Ethics Board conducts the ethics review, which improves efficiency and reduces the administrative burden. New application forms, a Quick Guide and an Informed Consent Formfor observational studies are available in CTO Stream.